Pierre Savatier (SBRI) has invited Isabelle Dusanter, from Institut Cochin (Paris Descartes) and she will give a talk on:
The RNA binding proteins PUMILIO and their target FOXP1, a new signaling pathway to sustain hematopoietic stem cell activity
RNA-binding proteins (RBPs) have emerged as important regulators of invertebrate adult stem cells, but their activities remain poorly appreciated in mammals. Using a short hairpin RNA strategy, we demonstrate here that the 2 mammalian RBPs, PUMILIO (PUM)1 and PUM2, members of the PUF family of posttranscriptional regulators, are essential for hematopoietic stem/progenitor cell (HSPC) proliferation and survival in vitro and in vivo upon reconstitution assays.
SBRI conference room, June 14th from 11am