CRNL Seminar
Monday, September 15, 2014 - 11:00am

Teams Neuropain and DYCOG have the pleasure to host Marcos G. Frank from the Center for Sleep and Circadian Neurobiology of the School of Medicine of the University of Pennsylvania. He will give a talk on:
Sleep to weaken, sleep to strengthen: An integrative view of sleep and synaptic plasticity
It will take place in the Inserm Building conference room - 151 Cours Albert Thomas - 69003 Lyon
The talk is part of the "sleep datablitz" day organized every year by the CRNL.
About Marcos G. Frank:
Marcos Frank received his PhD in Neuroscience at Stanford University in 1997, where he worked in the laboratory of H. Craig Heller studying the ontogenesis of sleep and sleep regulation in rodents.  This line of research provided new insights into sleep homeostasis in infancy and how this and related processes are altered by fetal exposure to psychoactive compounds. He then conducted post-doctoral research in the laboratory of Michael P. Stryker at the University of California, San Francisco demonstrating a role for sleep in a canonical form of in vivo cortical synaptic plasticity, originally described by David Hubel and Torsten Wiesel. He has continued this line of research as an Associate Professor at the University of Pennsylvania since 2003. Among other discoveries, the Frank lab has shown that sleep is associated with the activation of glutamate receptors and enzymatic pathways that consolidate experience-dependent plasticity in the cortex. A second line of research is focused on the role of glial astrocytes in sleep regulation. In collaboration with Dr.’s Phil Haydon and Ted Abel, Dr. Frank and his colleagues showed that astrocytic gliotransmission (i.e. the release of neurotransmitters by astrocytes) plays an important role in sleep homeostasis.  Both research topics are active areas of investigation in the Frank laboratory, and work along these lines has appeared in the Journals Neuron, Current Biology, Proceedings of the National Academy of Sciences, Journal of Neuroscience and SLEEP. Dr. Frank is also the author of several review articles and book chapters on the topics of glial regulation of sleep, sleep function and the role of sleep in brain plasticity, and is the senior editor of Current Advances in Sleep Biology (Nova Biomedical Books, 2009) and Brain Activity in Sleep (Elsevier, 2012).