Angela Sirigu is delighted to welcome Eric Burguière from the ICM in paris to come and give a talk on:
Probing the neurophysiological basis of compulsive behaviors
Increasing evidence points to abnormalities in cortico-basal ganglia circuitry as central to the pathophysiology of compulsive disorder. Parallels between the emergence of compulsions and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. I will address these question by presenting studies where we developed an optogenetic approach to block maladaptive compulsive behavior in a mouse model of OCD. We identified in this model a selective deficit in behavioral response inhibition associated with a malfunctioning striatal interneurons network. Both behavioral and electrophysiological phenotypes could be restored with selective optogenetic stimulation of the orbitofronto-striatal pathway. I will also discuss our current investigations aiming at better characterizing the endophenotypes that could underlie compulsive behavior such as deficit in behavioral flexibility or checking behaviors.
Location: Amphi ISC
Date: April 5th from 12pm